AstraZeneca, Sputnik vaccines face hurdles if Covid-19 shots become annual affair

ZURICH (REUTERS) – Vaccines from AstraZeneca , Russia’s Gamaleya Institute and Johnson & Johnson fight the coronavirus with another virus, leaving scientists concerned the shots may lose potency if annual inoculations become necessary to fight new variants.

So-called viral vector shots – also used by several Chinese Covid-19 vaccine developers – use harmless modified viruses as vehicles, or vectors, to carry genetic information that helps the body build immunity against future infections.

However, there is a risk that the body also develops immunity to the vector itself, recognising it as an intruder and trying to destroy it.

Most vector-vaccine developers have opted to use an adenovirus, a harmless class of common-cold viruses.

“The experience with adenoviruses has been for many years that vectors can be intercepted by the immune system after repeat injections,” said Professor Bodo Plachter, deputy director of the Institute of Virology at Mainz University’s teaching hospital.

“There may be the same problem with other types of vectors. Only ‘trial and error’ will tell,” he added.

That potentially puts vector vaccines at a disadvantage to mRNA shots from Pfizer and Moderna, or vaccines using deactivated coronaviruses, like Sinovac’s, or the coronavirus’ surface spike proteins, an approach pursued by Novavax.

Vector immunity is not a new issue but has come under renewed scrutiny as companies including J&J anticipate regular Covid-19 vaccinations, like annual influenza shots, may be needed to combat new variants of the coronavirus.

Moderna as well as Pfizer and partner BioNTech said in separate statements this week they are studying additional booster shots that target new variants over time.

Even without any evolution in the virus, it is not yet clear whether vaccine-induced immune memory will eventually wane, which would also require booster shots.

Mix and match

Scientists who spoke with Reuters acknowledged that no definitive conclusions can be drawn about vector immunity’s ultimate impact.

While it may prove surmountable in the end, health policymakers will still have to grapple with the question of which vaccines to deploy, and in what order, ahead of potential repeat inoculations.

A major validation of vector technology was the approval of Merck & Co’s Ervebo inoculation against Ebola in 2019 and its use – and that of similar experimental vaccines – during outbreaks in Africa in prior years.

But vector immunity has been implicated in past failures, including when a 2004 Merck Aids vaccine trial flopped in men previously exposed to the adenovirus used for the vaccine.

AstraZeneca declined to comment. J&J and the Russian Direct Investment Fund, which is responsible for marketing the Sputnik vaccine made by the Gamaleya Institute abroad, did not respond to a request for comment.

One approach could be to combine different shots, known as “mixing and matching”.

More on this topic

AstraZeneca and partner Oxford University’s shot is being trialled with Russia’s Sputnik V, and British scientists are testing Pfizer’s mRNA shot with AstraZeneca’s vaccine in a study funded by the British government, which says it is aware of the vector immunity issue.

The main motive for the British combination trial was to give healthcare providers flexibility in case of limited supplies, but Associate Professor Matthew Snape, the Oxford vaccinologist leading the project, said the question of vector immunity “is one of the reasons this study is interesting”.

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